Neurodegenerative diseases (ND) remains to be one of the biggest burdens on healthcare
systems and serves as a leading cause of disability and death. Alzheimer's disease (AD) is …

Salivary analysis is gaining increasing interest as a novel and promising field of research for
the diagnosis of neurodegenerative and demyelinating diseases related to aging. The …

Saliva testing is a vital method for clinical applications, for its noninvasive features, richness
in substances, and the huge amount. Due to its direct anatomical connection with oral …

Background Huntington's disease (HD) is an autosomal dominant disease caused by an
abnormally high number of CAG repeats at the huntingtin-encoding gene, HTT. This genetic …

Background Inflammatory responses play key roles in the development and progression of
many pathological conditions, including neurodegenerative diseases. Accurate …

Interleukin 33 (IL-33) belongs to the IL-1 family and is localized in the nucleus. IL-33 is
primarily composed of three distinct domains, namely the N-terminal domain responsible for …

Huntington's disease (HD) is a rare, inherited disorder with a broad spectrum of
manifestations that vary with disease severity and progression. Although genetic testing can …

Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic
disorder with a variable phenotype and rate of progression. We aimed to develop and …

Among the main challenges in further advancing therapeutic strategies for Huntington's
disease (HD) is the development of biomarkers which must be applied to assess the …

Nowadays human saliva is more frequently studied as a non-invasive, stress-free, and
preferable diagnostic material than blood. Supporting evidences acknowledge saliva as a …