Chronic wounds are characterized by delayed and dysregulated healing processes. As
such, they have emerged as an increasingly significant threat. The associated morbidity and …

The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a
key player in pathogenic ocular neovascularization almost a decade ago. Since then, an …

Delayed wound healing causes problems for many patients both physically and
psychologically, contributing to pain, economic burden, loss of function, and even …

Background: Macrophage infiltration around lipotoxic tubular epithelial cells (TECs) is a
hallmark of diabetic nephropathy (DN). However, how these two types of cells communicate …

Diabetic keratopathy (DK) is an important diabetic complication at the ocular surface.
Chronic low-grade inflammation mediated by the NLRP3 inflammasome promotes …

Immune dysfunction is widely regarded as one of the central tenants underpinning the
pathophysiology of diabetes mellitus (DM) and its complications. When discussing immunity …

Chronic wounds are a major health problem with increasing global prevalence, which
endangers the physical and mental health of those affected and is a heavy burden to …

Diabetic skin ulcer is one of the most severe complications in diabetes, however, current
therapeutic approaches are not effective enough. Agents modulating oxidative stress …

Retinal and choroidal diseases are major causes of blindness and visual impairment in the
developed world and on the rise due to an ageing population and diabetes epidemic …

Background Diabetic foot ulcers (DFU), affecting a quarter of diabetic patients and leading to
high rates of amputation and mortality, pose significant health and economic burdens …