Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

The purpose of this review was to evaluate data generated by animal models of
intervertebral disc (IVD) degeneration published in the last decade and show how this has …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

Satellite glial cells (SGCs) are among the most abundant non-neuronal cells in dorsal root
ganglia (DRGs) and closely envelop sensory neurons that detect painful stimuli. However …

Current treatments for chronic pain rely largely on opioids despite their substantial side
effects and risk of addiction. Genetic studies have identified in humans key targets pivotal to …

Chemotherapy-induced peripheral neuropathy is among the most common dose-limiting
adverse effects of cancer treatment, leading to dose reduction and discontinuation of life …

Background Nonsteroidal anti-inflammatory drugs are used to relieve sciatica, but their
effects are not satisfactory. Purpose This study aimed to explore the therapeutic effects of …

Rationale: Psoriasis is a chronic inflammatory disease caused by a complex interplay
between the immune and nervous systems with recurrent scaly skin plaques, thickened …

Nanotechnology has emerged as a promising approach for the targeted delivery of
therapeutic agents while improving their efficacy and safety. As a result, nanomaterial …

Pain is a common clinical condition. However, the mechanisms underlying pain are not yet
fully understood. It is known that the neuroimmune system plays a critical role in the …