In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter
release and in triggering alterations in neuronal function. Calmodulin has been widely …

Ca2+ plays a central role in the function of neurons as the trigger for neurotransmitter
release, and many aspects of neuronal activity, from rapid modulation to changes in gene …

CID-MS/MS cleavable cross-linkers hold an enormous potential for an automated analysis of
cross-linked products, which is essential for conducting structural proteomics studies. The …

Intracellular neuronal calcium sensors (NCS) constitute a rapidly growing family of calcium-
binding proteins which belong to the superfamily of EF-hand proteins. The NCS family …

Guanylyl cyclases (GCs) and adenylyl cyclases (ACs) have fundamental roles in a wide
range of cellular processes. Whereas GCs use GTP as a substrate to form cGMP, ACs …

Photoreceptor membrane guanylate cyclases (RetGC) are regulated by calcium-binding
proteins, GCAP-1 and GCAP-2. At Ca 2+ concentrations below 100 nm, characteristic of light …

Guanylyl cyclase activating protein-2 (GCAP-2) is a Ca 2+-sensitive regulator of
phototransduction in retinal photoreceptor cells. GCAP-2 activates retinal guanylyl cyclases …

Neuronal calcium sensor (NCS) proteins, a sub-branch of the calmodulin superfamily, are
expressed in the brain and retina where they transduce calcium signals and are genetically …

The GUCY2D gene encodes retinal membrane guanylyl cyclase (RetGC1), a key
component of the phototransduction machinery in photoreceptors. Mutations in GUCY2D …

It is well established that mutations in the presenilin 1 and 2 genes cause the majority of
early onset Alzheimer's disease (AD). However, our understanding of the cellular functions …