Physics and biomedical challenges of cancer therapy with accelerated heavy ions

M Durante, J Debus, JS Loeffler - Nature Reviews Physics, 2021 - nature.com
Radiotherapy should have low toxicity in the entrance channel (normal tissue) and be very
effective in cell killing in the target region (tumour). In this regard, ions heavier than protons …

Radioactive beams in particle therapy: past, present, and future

M Durante, K Parodi - Frontiers in physics, 2020 - frontiersin.org
Heavy ion therapy can deliver high doses with high precision. However, image guidance is
needed to reduce range uncertainty. Radioactive ions are potentially ideal projectiles for …

Radioactive beams for image-guided particle therapy: The BARB experiment at GSI

D Boscolo, D Kostyleva, MJ Safari… - Frontiers in …, 2021 - frontiersin.org
Several techniques are under development for image-guidance in particle therapy. Positron
(β+) emission tomography (PET) is in use since many years, because accelerated ions …

Quasi-real-time range monitoring by in-beam PET: a case for 15O

S Purushothaman, D Kostyleva, P Dendooven… - Scientific Reports, 2023 - nature.com
A fast and reliable range monitoring method is required to take full advantage of the high
linear energy transfer provided by therapeutic ion beams like carbon and oxygen while …

Precision of the PET activity range during irradiation with 10C, 11C, and 12C beams

D Kostyleva, S Purushothaman… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective. Beams of stable ions have been a well-established tool for radiotherapy for many
decades. In the case of ion beam therapy with stable 12 C ions, the positron emitters 10, 11 …

A validated Geant4 model of a whole-body PET scanner with four-layer DOI detectors

AM Ahmed, A Chacon, H Rutherford… - Physics in Medicine …, 2020 - iopscience.iop.org
The purpose of this work is to develop a validated Geant4 simulation model of a whole-body
prototype PET scanner constructed from the four-layer depth-of-interaction detectors …

Microstructural and mechanical analyses of YBCO coated conductor tapes in high-irradiation environments

Y Pan, C Xin, W Wu, M Guan, X Wang - Fusion Engineering and Design, 2025 - Elsevier
Upgrading the superconducting magnets in the High Energy Fragment Separator (HFRS) at
the High Intensity Heavy Ion Accelerator Facility (HIAF) is challenging due to the complex …

β-delayed multiple-particle emitters minibeam radiation therapy: first dosimetric evaluation with Monte Carlo simulations

A Corvino, T Schneider, Y Prezado - Frontiers in Physics, 2024 - frontiersin.org
Radiation therapy, one of the most effective methods for cancer treatment, is still limited by
the tolerances of normal tissues surrounding the tumor. Innovative techniques like spatially …

A quantitative assessment of Geant4 for predicting the yield and distribution of positron-emitting fragments in ion beam therapy

A Chacon, H Rutherford, A Hamato… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective. To compare the accuracy with which different hadronic inelastic physics models
across ten Geant4 Monte Carlo simulation toolkit versions can predict positron-emitting …

A Practical Primer on Particle Therapy

TD Malouff, M Newpower, A Bush… - Practical Radiation …, 2024 - Elsevier
Purpose Particle therapy is a promising treatment technique that is becoming more
commonly used. Although proton beam therapy remains the most commonly used particle …