Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease
T Athar, K Al Balushi, SA Khan - Molecular biology reports, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative old age disease that is complex,
multifactorial, unalterable, and progressive in nature. The currently approved therapy …
multifactorial, unalterable, and progressive in nature. The currently approved therapy …
Regionalization of intestinal microbiota and metabolites in the small intestine of the Bactrian camel
Y Cheng, Y Ren, W Zhang, J Lu, F Xie… - Frontiers in …, 2024 - frontiersin.org
Introduction Peyer's patches (PPs) are crucial antigen-inductive sites of intestinal mucosal
immunity. Prior research indicated that, in contrast to other ruminants, PPs in the small …
immunity. Prior research indicated that, in contrast to other ruminants, PPs in the small …
Acetylation and phosphorylation processes modulate Tau's binding to microtubules: A molecular dynamics study
The microtubule-associated protein Tau has its normal function impaired when undergoing
post-translational modifications. In this work, molecular modelling techniques were used to …
post-translational modifications. In this work, molecular modelling techniques were used to …
[HTML][HTML] Kefir peptides exhibit antidepressant-like activity in mice through the BDNF/TrkB pathway
Depression is a prevalent, stress-related mental disorder that can lead to serious psychiatric
diseases with morbidity and high mortality. Although some functional fermented dairy drinks …
diseases with morbidity and high mortality. Although some functional fermented dairy drinks …
Effects of 12 weeks colostrum milk supplement among older adults: A randomised, double-blind and placebo-controlled trial
The effects of milk intake, particularly bovine colostrum-enriched skim milk among older
adults, were investigated. Sixty-six adults aged 50–69 years old were recruited for a 12 …
adults, were investigated. Sixty-six adults aged 50–69 years old were recruited for a 12 …
Domain focused and residue focused phosphorylation effect on tau protein: A molecular dynamics simulation study
Phosphorylation has been hypothesized to alter the ability of tau protein to bind with
microtubules (MT), and pathological level of phosphorylation can incorporate formation of …
microtubules (MT), and pathological level of phosphorylation can incorporate formation of …
[PDF][PDF] Sobczy nski
M Sochocka, M Ochnik - geriatrics, 2021 - academia.edu
Background: One of the main features of Alzheimer's disease (AD) pathology is failure in
innate immune response and chronic inflammation. Lack of effective AD treatment means …
innate immune response and chronic inflammation. Lack of effective AD treatment means …
Ginkgo biloba leaf extract improves an innate immune response of peripheral blood leukocytes of Alzheimer's disease patients
Background: One of the main features of Alzheimer's disease (AD) pathology is failure in
innate immune response and chronic inflammation. Lack of effective AD treatment means …
innate immune response and chronic inflammation. Lack of effective AD treatment means …
Sex differences in innate immune response of peripheral blood leukocytes of Alzheimer's disease patients
Neurodegenerative disorders, including Alzheimer's disease (AD), are associated with a
disruption of normal immune function that could potentially impact the brain. In AD sex and …
disruption of normal immune function that could potentially impact the brain. In AD sex and …
Effect of strain rate on single tau, dimerized tau and tau-microtubule interface: A molecular dynamics simulation study
Microtubule-associated protein (MAP) tau is a cross-linking molecule that provides structural
stability to axonal microtubules (MT). It is considered a potential biomarker for Alzheimer's …
stability to axonal microtubules (MT). It is considered a potential biomarker for Alzheimer's …