Tumor hypoxia: From basic knowledge to therapeutic implications

C Liao, X Liu, C Zhang, Q Zhang - Seminars in cancer biology, 2023 - Elsevier
Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

HIF transcription factors, inflammation, and immunity

A Palazon, AW Goldrath, V Nizet, RS Johnson - Immunity, 2014 - cell.com
The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible
factor (HIF) transcription factors; these play an integral role in the metabolic changes that …

Hypoxia-driven immune escape in the tumor microenvironment

A Vito, N El-Sayes, K Mossman - Cells, 2020 - mdpi.com
The tumor microenvironment is a complex ecosystem comprised of many different cell types,
abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with …

Coordinated regulation of myeloid cells by tumours

DI Gabrilovich, S Ostrand-Rosenberg… - Nature Reviews …, 2012 - nature.com
Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and
are a collection of distinct cell populations with many diverse functions. The three groups of …

Immunity, hypoxia, and metabolism–the Ménage à Trois of cancer: implications for immunotherapy

C Riera-Domingo, A Audigé, S Granja… - Physiological …, 2020 - journals.physiology.org
It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

Regulation of human macrophage M1–M2 polarization balance by hypoxia and the triggering receptor expressed on myeloid cells-1

F Raggi, S Pelassa, D Pierobon, F Penco… - Frontiers in …, 2017 - frontiersin.org
Macrophages (Mf) are a heterogeneous population of tissue-resident professional
phagocytes and a major component of the leukocyte infiltrate at sites of inflammation …

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

U Fearon, M Canavan, M Biniecka… - Nature Reviews …, 2016 - nature.com
Synovial proliferation, neovascularization and leukocyte extravasation transform the
normally acellular synovium into an invasive tumour-like'pannus'. The highly dysregulated …

[HTML][HTML] Deciphering and reversing tumor immune suppression

GT Motz, G Coukos - Immunity, 2013 - cell.com
Generating an anti-tumor immune response is a multi-step process that is executed by
effector T cells that can recognize and kill tumor targets. However, tumors employ multiple …

[HTML][HTML] The role of HIF in immunity and inflammation

AF McGettrick, LAJ O'Neill - Cell metabolism, 2020 - cell.com
HIF is a transcription factor that plays an essential role in the cellular response to low
oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In …

Hypoxia and innate immunity: keeping up with the HIFsters

SP Colgan, GT Furuta, CT Taylor - Annual review of …, 2020 - annualreviews.org
Recent years have witnessed an emergence of interest in understanding metabolic changes
associated with immune responses, termed immunometabolism. As oxygen is central to all …