▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a
wide array of developmental processes. Over 240 HLH proteins have been identified to date …

Linking regulatory DNA elements to their target genes, which may be located hundreds of
kilobases away, remains challenging. Here, we introduce Cicero, an algorithm that identifies …

CREB binding protein (CBP) and p300 were both identified initially in protein interaction
assays–the former through its association with the transcription factor CREB (Chrivia et al …

▪ Abstract Metazoans contain multiple types of muscle cells that share several common
properties, including contractility, excitability, and expression of overlapping sets of muscle …

The heart responds to stress signals by hypertrophic growth, which is accompanied by
activation of the MEF2 transcription factor and reprogramming of cardiac gene expression …

Members of the myocyte enhancer factor-2 (MEF2) family of transcription factors associate
with myogenic basic helix–loop–helix transcription factors such as MyoD to activate skeletal …

The transcriptional coactivator and integrator p300 and its closely related family member
CBP mediate multiple, signal-dependent transcriptional events. We have generated mice …

The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4
have critical roles in skeletal muscle development. Together with the Mef2 proteins and E …

The expression of Myod is sufficient to convert a fibroblast to a skeletal muscle cell, and, as
such, is a model system in developmental biology for studying how a single initiating event …