In the last few years there has been a veritable explosion of knowledge about cyclic
nucleotide phosphodiesterases. In particular, the accumulating data showing that there are …

Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Cyclic GMP (cGMP) made in response to atrial natriuretic peptide (ANP) or nitric oxide (NO)
is an important regulator of short-term changes in smooth muscle tone and longer-term …

Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of
cardiac function by degrading cAMP and cGMP. In cardiomyocytes, multiple PDE isozymes …

Over the past 5 years there has been an explosion of new information on the physiological
and pathophysiological roles of NO within the heart as in other organ systems. In this review …

From the‡ Section for Molecular Signaling, Department of Cell and Molecular Biology, Lund
University, S-221 00 Lund, Sweden and¶ Pulmonary/Critical Care Medicine Branch, NHLBI …

A current challenge in cellular signaling is to decipher the complex intracellular
spatiotemporal organization that any given cell type has developed to discriminate among …

Complex paracrine interactions exist between endothelial cells and cardiac myocytes in the
heart. Cardiac endothelial cells release (or metabolize) several diffusible agents (eg, nitric …

The different cell types comprising cardiac muscle express one or more of the three isoforms
(neuronal NOS, or nNOS; inducible NOS, or iNOS; and endothelial NOS, or eNOS) of nitric …