Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …

Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

Recent studies examining the neurobiology of substance abuse have revealed a significant
role of neuroimmune signaling as a mechanism through which drugs of abuse induce …

While the immune system is essential for survival, an excessive or prolonged inflammatory
response, such as that resulting from sustained heavy alcohol use, can damage the host …

Several studies have supported the association between maternal immune activation (MIA)
caused by exposure to pathogens or inflammation during critical periods of gestation and an …

Alcohol consumption is known to cause several brain anomalies. The pathophysiological
changes associated with alcohol intoxication are mediated by various factors, most notable …

Binge drinking is rising among aged adults (> 65 years of age), however the contribution of
alcohol misuse to neurodegenerative disease development is not well understood. Both …

Stress and substance use disorders remain two of the most highly prevalent psychiatric
conditions and are often comorbid. While individually these conditions have a debilitating …

Depression is a heterogeneous disorder and associated with inflammatory responses. The
influences of N-acetylcysteine (NAC) on neuroinflammation associated depression-like …