An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases

DM Teleanu, AG Niculescu, II Lungu, CI Radu… - International journal of …, 2022 - mdpi.com
Oxidative stress has been linked with a variety of diseases, being involved in the debut
and/or progress of several neurodegenerative disorders. This review intends to summarize …

Ageing as a risk factor for neurodegenerative disease

Y Hou, X Dan, M Babbar, Y Wei… - Nature Reviews …, 2019 - nature.com
Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer
disease (AD) and Parkinson disease (PD). One in ten individuals aged≥ 65 years has AD …

Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7

S Deshwal, M Onishi, T Tatsuta, T Bartsch, E Cors… - Nature cell …, 2023 - nature.com
Coenzyme Q (or ubiquinone) is a redox-active lipid that serves as universal electron carrier
in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid …

Oxidative damage and antioxidant defense in ferroptosis

F Kuang, J Liu, D Tang, R Kang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Many new types of regulated cell death have been recently implicated in human health and
disease. These regulated cell deaths have different morphological, genetic, biochemical …

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

M Jakaria, AA Belaidi, AI Bush… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Metabolic and vascular effect of the Mediterranean diet

A Tuttolomondo, I Simonetta, M Daidone… - International journal of …, 2019 - mdpi.com
Several studies indicated how dietary patterns that were obtained from nutritional cluster
analysis can predict disease risk or mortality. Low-grade chronic inflammation represents a …

Statin-associated myopathy: emphasis on mechanisms and targeted therapy

P Vinci, E Panizon, LM Tosoni, C Cerrato… - International journal of …, 2021 - mdpi.com
Hyperlipidemia is a major risk factor for cardiovascular morbidity and mortality. Statins are
the first-choice therapy for dyslipidemias and are considered the cornerstone of …

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

DJM Fernández-Ayala, P Navas… - Experimental gerontology, 2020 - Elsevier
SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

Iron brain menace: the involvement of ferroptosis in Parkinson disease

KJ Lin, SD Chen, KL Lin, CW Liou, MY Lan… - Cells, 2022 - mdpi.com
Parkinson disease (PD) is the second-most common neurodegenerative disease. The
characteristic pathology of progressive dopaminergic neuronal loss in people with PD is …

Nutraceutical approach to non-alcoholic fatty liver disease (NAFLD): the available clinical evidence

AFG Cicero, A Colletti, S Bellentani - Nutrients, 2018 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a clinical condition characterized by lipid
infiltration of the liver, highly prevalent in the general population affecting 25% of adults, with …