Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design of antibacterial drugs which can be effective against both Gram-positive and Gram-negative …
L Zimmermann, A Bussière, M Ouberai… - Journal of medicinal …, 2013 - ACS Publications
Aminoglycosides are antibiotic drugs that act through binding to rRNA. In the search for antimicrobial amphiphilic aminoglycosides targeting bacterial membranes, we report here …
Unambiguous assignments have been made for each individual p K a value of the amino group and guanidine substituents on 2-deoxystreptamine, neamine, neomycin …
SM Williams, JS Brodbelt… - Journal of the American …, 2003 - ACS Publications
Lariat ethers with pendant amide groups have shown promise as new ion sensors because of their selectivity towards particular metal ions. In this study we report alkali and alkaline …
M Perigolo de Oliveira, JF Constant… - Chemical Research …, 2013 - ACS Publications
Abasic sites are probably the most common lesions in DNA resulting from the hydrolytic cleavage of glycosidic bonds that can occur spontaneously and through DNA alkylation by …
CA Andac, TC Stringfellow, U Hornemann… - Bioorganic …, 2011 - Elsevier
The dependence of the solution structure of neamine on pH was determined by NMR and AMBER molecular dynamics methods at pD 3.3, pD 6.5, and pD 7.4 in D2O at 25° C. Unlike …