Although human tenocytes and dermal fibroblasts have shown promise in tendon
engineering, no tissue engineered medicine has been developed due to the prolonged ex …

Macromolecular crowding (MMC) enhances and accelerates extracellular matrix (ECM)
deposition in eukaryotic cell culture. Single hyaluronic acid (HA) molecules have not …

Enthesis repair remains a challenging clinical indication. Herein, a three-layer scaffold
composed of a tendon-like layer of collagen type I, a fibrocartilage-like layer of collagen type …

Modern bioengineering utilises biomimetic cell culture approaches to control cell fate during
in vitro expansion. In this spirit, herein we assessed the influence of bidirectional surface …

The combined effect of surface topography and substrate rigidity in stem cell cultures is still
under‐investigated, especially when biodegradable polymers are used. Herein, we …

Tendinopathy is characterised by pathological changes in tendon matrix composition,
architecture, and stiffness, alterations in tendon resident cell characteristics, and fibrosis …

Current in vitro models poorly represent the healthy or diseased tendon microenvironment,
limiting the translation of the findings to clinics. The present work aims to establish a …

Energy storing tendons such as the human Achilles and equine superficial digital flexor
tendon (SDFT) are prone to injury, with incidence increasing with aging, peaking in the 5 th …

The absence of a native extracellular matrix and the use of xenogeneic sera are often
associated with rapid tenocyte function losses during in vitro culture. Herein, we assessed …

Allogeneic serum and tissue-specific extracellular matrix have been shown to maintain
permanently differentiated cell phenotype in culture. This is of particular importance for …