The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

ABSTRACT Preclinical Research MicroRNAs (miRNAs) are small endogenous noncoding
RNAs that suppress gene expression at the post‐transcriptional level. In the past decade …

MicroRNAs comprise a broad class of small non-coding RNAs that control expression of
complementary target messenger RNAs,. Dysregulation of microRNAs by several …

In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that
parallels the increased prevalence of obesity and which markedly increases the risk of …

Acute myocardial infarction (MI) due to coronary artery occlusion is accompanied by a
pathological remodeling response that includes hypertrophic cardiac growth and fibrosis …

Abstract miRNAs (or microRNAs) are small, endogenous, and noncoding RNAs construct of
about 22 nucleotides. Cumulative evidence from biological experiments shows that miRNAs …

The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the
transcription factor NF-κB and suppresses interleukin 10 (IL-10). Here we found that mice …

Since 1993, when the first small non-coding RNA was identified, our knowledge about
microRNAs has grown exponentially. In this review, we focus on the main progress in this …