Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH3 (edelfosine), a proapoptotic agent in tumor cells
C Gajate, F Mollinedo - Current drug metabolism, 2002 - ingentaconnect.com
The antitumor ether lipid ET-18-OCH3 (edelfosine) is the prototype of a new class of
antineoplastic agents, synthetic analogues of lysophosphatidylcholine, that shows a high …
antineoplastic agents, synthetic analogues of lysophosphatidylcholine, that shows a high …
ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor
F Mollinedo, C Gajate… - Current medicinal …, 2004 - ingentaconnect.com
Synthetic ether-linked analogues of phosphatidylcholine and lysophosphatidylcholine,
collectively named as antitumour lipids (ATLs), were initially synthesized in the late 60s, but …
collectively named as antitumour lipids (ATLs), were initially synthesized in the late 60s, but …
[HTML][HTML] Ceramide/sphingomyelin rheostat regulated by sphingomyelin synthases and chronic diseases in murine models
M Taniguchi, T Okazaki - Journal of Lipid and Atherosclerosis, 2020 - ncbi.nlm.nih.gov
Ceramide and sphingomyelin (SM) are major components of the double membrane-bound
sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes …
sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes …
Activation of LFA-1 through a Ca2 (+)-dependent epitope stimulates lymphocyte adhesion.
Y van Kooyk, P Weder, F Hogervorst… - The Journal of cell …, 1991 - rupress.org
The leukocyte function-associated molecule-1 (LFA-1) plays a key role in cell adhesion
processes between cells of the immune system. We investigated the mechanism that may …
processes between cells of the immune system. We investigated the mechanism that may …
Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion
WJ van Blitterswijk, H Hilkmann, GA Storme - Lipids, 1987 - Springer
Tumor cells grown in the presence of 1-O-alkyl-2-O-methylglycero-3-phosphocholine (AMG-
PC) accumulated this ether lipid in their membranes. Depending on the cell type and the …
PC) accumulated this ether lipid in their membranes. Depending on the cell type and the …
Metabolism of ether phospholipids and analogs in neoplastic cells
EAM Fleer, C Unger, DJ Kim, H Eibl - Lipids, 1987 - Wiley Online Library
The ether phospholipid 1‐O‐octadecyl‐2‐O‐methyl‐rac‐glycero‐3‐phosphocholine (OM‐
GPC) is known to be a potent inhibitor of cell growth. Metabolic studies in both Raji and …
GPC) is known to be a potent inhibitor of cell growth. Metabolic studies in both Raji and …
Phospholipid metabolism in bradykinin-stimulated human fibroblasts. II. Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C
WJ van Blitterswijk, H Hilkmann, J De Widt… - Journal of Biological …, 1991 - Elsevier
Bradykinin (BK) and phorbol 12-myristate 13-acetate (PMA) both stimulate the hydrolysis of
phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic …
phosphatidylcholine (PC) in human fibroblasts, resulting in the formation of phosphatidic …
Sensitivity of K562 and HL-60 cells to edelfosine, an ether lipid drug, correlates with production of reactive oxygen species
BA Wagner, GR Buettner, LW Oberley, CP Burns - Cancer research, 1998 - AACR
Abstract Edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; ET-18-
OCH3), a membrane-targeting anticancer ether lipid drug has been shown previously in …
OCH3), a membrane-targeting anticancer ether lipid drug has been shown previously in …
Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species
JS Liou, CY Chen, JS Chen, DV Faller - Journal of Biological Chemistry, 2000 - ASBMB
Ras is a well established modulator of apoptosis. Suppression of protein kinase C (PKC)
activity can selectively induce apoptosis in cells expressing a constitutively activated Ras …
activity can selectively induce apoptosis in cells expressing a constitutively activated Ras …
Transport of influenza HA from the trans-Golgi network to the apical surface of MDCK cells permeabilized in their basolateral plasma membranes: energy dependence …
D Gravotta, M Adesnik, DD Sabatini - The Journal of cell biology, 1990 - rupress.org
A procedure employing streptolysin O to effect the selective permeabilization of either the
apical or basolateral plasma membrane domains of MDCK cell monolayers grown on a filter …
apical or basolateral plasma membrane domains of MDCK cell monolayers grown on a filter …