[HTML][HTML] The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy
The cancer stem-cell (CSC) hypothesis suggests that there is a small subset of cancer cells
that are responsible for tumor initiation and growth, possessing properties such as indefinite …
that are responsible for tumor initiation and growth, possessing properties such as indefinite …
Stem cell gene expression programs influence clinical outcome in human leukemia
Xenograft studies indicate that some solid tumors and leukemias are organized as cellular
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model …
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model …
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21. 1 losses in malignant pleural mesothelioma
Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation, but
other highly recurrent mutations have not been described. To identify additional driver …
other highly recurrent mutations have not been described. To identify additional driver …
Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell–Like Properties and Epithelial–Mesenchymal …
SH Chiou, ML Wang, YT Chou, CJ Chen, CF Hong… - Cancer research, 2010 - AACR
Abstract Epithelial–mesenchymal transition (EMT), a critical process of cancer invasion and
metastasis, is associated with stemness property of cancer cells. Though Oct4 and Nanog …
metastasis, is associated with stemness property of cancer cells. Though Oct4 and Nanog …
Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
CM Fillmore, PB Gupta, JA Rudnick… - Proceedings of the …, 2010 - National Acad Sciences
Many tumors contain heterogeneous populations of cells, only some of which exhibit
increased tumorigenicity and resistance to anticancer therapies. Evidence suggests that …
increased tumorigenicity and resistance to anticancer therapies. Evidence suggests that …
Notch pathway activity identifies cells with cancer stem cell–like properties and correlates with worse survival in lung adenocarcinoma
Purpose: The cancer stem cell theory postulates that tumors contain a subset of cells with
stem cell properties of self-renewal, differentiation, and tumor initiation. The purpose of this …
stem cell properties of self-renewal, differentiation, and tumor initiation. The purpose of this …
[PDF][PDF] Musashi1: an RBP with versatile functions in normal and cancer stem cells
RI Glazer, DT Vo, LO Penalva - Front Biosci, 2012 - article.imrpress.com
[Frontiers in Bioscience 17, 54-64, January 1, 2012] 54 Musashi1: an RBP with versatile
functions in normal and cancer stem ce Page 1 [Frontiers in Bioscience 17, 54-64, January 1 …
functions in normal and cancer stem ce Page 1 [Frontiers in Bioscience 17, 54-64, January 1 …
PADI2‐catalyzed MEK1 citrullination activates ERK1/2 and promotes IGF2BP1‐mediated SOX2 mRNA stability in endometrial cancer
T Xue, X Liu, M Zhang, QE, S Liu, M Zou, Y Li… - Advanced …, 2021 - Wiley Online Library
Peptidylarginine deiminase II (PADI2) converts positively charged arginine residues to
neutrally charged citrulline, and this activity has been associated with the onset and …
neutrally charged citrulline, and this activity has been associated with the onset and …
Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma
LM Sholl, JA Barletta, BY Yeap… - The American journal …, 2010 - journals.lww.com
Many patients with stage I nonsmall cell lung carcinoma will develop recurrence after
surgical excision. Sox2 is a marker of embryonic stem cell pluripotency that is associated …
surgical excision. Sox2 is a marker of embryonic stem cell pluripotency that is associated …
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures
Breast cancer comprises a heterogeneous set of diseases distinguishable from one another
by pathologic presentation and molecular signatures. However, each breast cancer subtype …
by pathologic presentation and molecular signatures. However, each breast cancer subtype …