The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y

A Kask, J Harro, S von Hörsten, JP Redrobe… - Neuroscience & …, 2002 - Elsevier
This review aims to give a brief overview of NPY receptor distribution and physiology in the
brain and summarizes series of studies, test by test and region by region, aimed at …

Neuropeptide Y receptors: how to get subtype selectivity

X Pedragosa-Badia, J Stichel… - Frontiers in …, 2013 - frontiersin.org
The neuropeptide Y (NPY) system is a multireceptor/multiligand system consisting of four
receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate …

Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates

M Shahab, C Mastronardi… - Proceedings of the …, 2005 - National Acad Sciences
To further study the role of GPR54 signaling in the onset of primate puberty, we used the
monkey to examine the ability of kisspeptin-10 to elicit the release of gonadotropin-releasing …

Molecular characterization of the ligand–receptor interaction of the neuropeptide Y family

C Cabrele, AG Beck‐Sickinger - Journal of peptide science: an …, 2000 - Wiley Online Library
Abstract Neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) belong
to the NPY hormone family and activate a class of receptors called the Y‐receptors, and also …

Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes

MM Berglund, PA Hipskind… - … biology and medicine, 2003 - journals.sagepub.com
The three peptides pancreatic polypeptide (PP), peptide YY (PYY), and neuropeptide Y
(NPY) share a similar structure known as the PP-fold. There are four known human G …

The neuropeptide Y system: pathophysiological and therapeutic implications in obesity and cancer

L Zhang, MS Bijker, H Herzog - Pharmacology & therapeutics, 2011 - Elsevier
The neuropeptide Y (NPY) system–comprising of neuropeptide Y, peptide YY, pancreatic
polypeptide and the corresponding Y receptors through which they act (Y1, Y2, Y4, Y5 and …

Physiological and therapeutic roles of neuropeptide Y on biological functions

P Shende, D Desai - Cell Biology and Translational Medicine, Volume 7 …, 2020 - Springer
Neuropeptide Y (NPY), an amino acid, used for various physiological processes for
management and treatment of various ailments related to central nervous system …

Roles of pancreatic polypeptide in regulation of food intake

G Katsuura, A Asakawa, A Inui - Peptides, 2002 - Elsevier
Pancreatic polypeptide (PP) is produced in pancreatic islets of Langerhans and released
into the circulation after ingestion of a meal. Peripherally administered PP suppresses food …

Neuropeptide Y and its receptors as potential therapeutic drug targets

AP Silva, C Cavadas, E Grouzmann - Clinica Chimica Acta, 2002 - Elsevier
Neuropeptide Y (NPY) is a 36-amino-acid peptide that exhibits a large number of
physiological activities in the central and peripheral nervous systems. NPY mediates its …

Enhancing functional production of G protein‐coupled receptors in Pichia pastoris to levels required for structural studies via a single expression screen

N André, N Cherouati, C Prual, T Steffan… - Protein …, 2006 - Wiley Online Library
We have optimized the expression level of 20 mammalian G protein‐coupled receptors
(GPCRs) in the methylotrophic yeast Pichia pastoris. We found that altering expression …