Publisher Summary The studies of retinoblastoma (RB) have been driven by three
hypotheses:(1) RB is the suppressor of retinoblastoma and possibly the other types of …

The retinoblastoma susceptibility gene is a tumour suppressor and its product
retinoblastoma protein (pRb) has been known for 10 years as a repressor of progression …

Consumption of diets rich in fruits and vegetables is often associated with a reduced risk of
developing cancer, particularly breast cancer. Considering that 1 in 8 women in the United …

Objective. Megakaryopoiesis is characterized by two major processes, acquisition of lineage-
specific markers and polyploidization. Polyploidy is a result of endomitosis, a process that is …

1α, 25 (OH) 2 vitamin D3 (1, 25 (OH) 2D3) can induce differentiation of osteoblastic cells by
arresting the cell cycle at G1. The p53-inducible gene, WAF1/Cip1, is one of the inhibitors of …

Human leukemic cell line K562 is induced to differentiate into the megakaryocytic lineage by
stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA). We demonstrate here that …

Megakaryocytic differentiation of myelogenous leukemia cell lines induced by a number of
chemical compounds mimics, in part, the physiological process that takes place in the bone …

We investigated whether members of the protein kinase C (PKC) family of enzymes could
play a role in the nuclear events involved in megakaryocytic differentiation. PKC activity was …

Natural killer (NK) cells target and kill tumor cells by direct anti-tumor cytotoxicity. NK lytic-
associated molecule (NKLAM) is a protein involved in this cytolytic function. Acting as an E3 …

We have studied the regulation and role of c-Myc and Max in the differentiation pathways
induced in K562 cells by 12-O-tetradecanoyl phorbol-13 acetate (TPA) and staurosporine …