Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Hearing loss (HL), or deafness in its most severe form, affects an estimated 28 and 22.5
million Americans and Europeans, respectively. The numbers are higher in regions such as …

Voltage-gated ion channels generate dynamic ionic currents that are vital to the
physiological functions of many tissues. These proteins contain separate voltage-sensing …

The KCNQ1 voltage-gated potassium channel and its auxiliary subunit KCNE1 play a crucial
role in the regulation of the heartbeat. The stoichiometry of KCNQ1 and KCNE1 complex has …

KCNE1 is a single-span membrane protein that modulates the voltage-gated potassium
channel KCNQ1 (KV7. 1) by slowing activation and enhancing channel conductance to …

The delayed rectifier IKs potassium channel, formed by coassembly of α-(KCNQ1) and β-
(KCNE1) subunits, is essential for cardiac function. Although KCNE1 is necessary to …

Voltage-gated ion channels generate electrical currents that control muscle contraction,
encode neuronal information, and trigger hormonal release. Tissue-specific expression of …

The functional properties of KCNQ1 channels are highly dependent on associated KCNE-β
subunits. Mutations in KCNQ1 or KCNE subunits can cause congenital channelopathies …

Gating of voltage-dependent cation channels involves three general molecular processes:
voltage sensor activation, sensor-pore coupling, and pore opening. KCNQ1 is a voltage …

The IKs channel complex is formed by the co-assembly of Kv7. 1 (KCNQ1), a voltage-gated
potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory …