Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …

This year in review on osteoarthritis biology summarizes a series of research articles
published between the 2020 and 2021 Osteoarthritis Research Society International …

The emerging therapeutic strategies for osteoarthritis (OA) are shifting toward
comprehensive approaches that target periarticular tissues, involving both cartilage and …

In spite of a major public health burden with increasing prevalence, current osteoarthritis
(OA) management is largely palliative with an unmet need for effective treatment. Both …

Osteoarthritis is a joint disease characterized by a poorly-defined inflammatory response
that does not encompass a massive immune cell infiltration yet contributes to cartilage …

Aberrant subchondral bone architecture is a crucial driver of the pathological progression of
osteoarthritis, coupled with increased sensory innervation. The sensory PGE2/EP4 pathway …

Senescence is a complex cell state characterized by stable cell cycle arrest and a unique
secretory pattern known as the senescence-associated secretory phenotype (SASP). The …

Osteoarthritis (OA) is the most prevalent arthritis with an estimated global prevalence in
2020 of 22.9%(95% confidence interval [CI], 19.8%-26.1%) in persons over 40 years of age …

Background: Metabolic syndrome–associated osteoarthritis (MetS-OA) is a distinct
osteoarthritis phenotype defined by the coexistence of MetS or its individual components …