Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to
be a promising therapeutic target for several neurodegenerative disorders, which includes …

Activated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and
consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric …

Macrophages are important innate immune cells that are associated with two distinct
phenotypes: a pro-inflammatory (or classically activated) subset with prototypic macrophage …

Circulating monocytes are recruited to tissues, where they differentiate to macrophages and
take part in the inflammation process or tissue remodeling. According to the traditional …

The renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and
most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In …

Lowered high-density lipoprotein (HDL) cholesterol has been reported in major depressive
disorder, bipolar disorder, first episode of psychosis, and schizophrenia. HDL, its major …

Obesity has reached pandemic proportion and represents a major risk for several
comorbidities. In addition to metabolic and cardiovascular obesity-related diseases, recent …

Nuclear receptors are important bridges between lipid signaling molecules and transcription
responses. Beside their role in several developmental and physiological processes, many of …

Abstract Nitro-fatty acids (NO 2-FA) are electrophilic lipid mediators derived from
unsaturated fatty acid nitration. These species are produced endogenously by metabolic …

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver
disease, reaching epidemic proportions worldwide. Targeting the gut–adipose tissue–liver …