The extraordinary rate accelerations and control of reactivity exhibited by enzymes have
long inspired efforts to develop synthetic catalysts. Foldamers, which are oligomers with a …

Time span in literature: 1985-early 2024Natural products play a key role in drug discovery,
both as a direct source of drugs and as a starting point for the development of synthetic …

The widespread success of BINOL-chiral phosphoric acids (CPAs) has led to the
development of several high molecular weight, sterically encumbered variants. Herein, we …

We report the catalytic stereocontrolled synthesis of dinucleotides. We have demonstrated,
for the first time to our knowledge, that chiral phosphoric acid (CPA) catalysts control the …

Biaryl compounds are extremely important structural motifs in natural products, biologically
active components and pharmaceuticals. Selective synthesis of biaryls by distinguishing the …

The application of mechanistic generalizations is at the core of chemical reaction
development and application. These strategies are rooted in physical organic chemistry …

The application of statistical modeling in organic chemistry is emerging as a standard
practice for probing structure-activity relationships and as a predictive tool for many …

Glycosylation is one of the most common and important modifications in natural products
(NPs), which can alter the biological activities and properties of NPs, effectively increase …

A chiral phosphoric acid with a 2, 2'‐binaphthol core was prepared that displays two
thioxanthone moieties at the 3, 3'‐position as light‐harvesting antennas. Despite its …

Acylation stands as a fundamental process in both biological pathways and synthetic
chemical reactions, with acylated saccharides and their derivatives holding diverse …