Comparing radiolytic production of H2O2 and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams

H Kacem, S Psoroulas, G Boivin, M Folkerts… - Radiotherapy and …, 2022 - Elsevier
The physico-chemical and biological response to conventional and UHDR electron and
proton beams was investigated, along with conventional photons. The temporal structure …

Passive SOBP generation from a static proton pencil beam using 3D-printed range modulators for FLASH experiments

F Horst, E Beyreuther, E Bodenstein, S Gantz… - Frontiers in …, 2023 - frontiersin.org
The University Proton Therapy facility in Dresden (UPTD), Germany, is equipped with an
experimental room with a beamline providing a static pencil beam. High proton beam …

[HTML][HTML] Dosimetric and biologic intercomparison between electron and proton FLASH beams

A Almeida, M Togno, P Ballesteros-Zebadua… - Radiotherapy and …, 2024 - Elsevier
Background and purpose The FLASH effect has been validated in different preclinical
experiments with electrons (eFLASH) and protons (pFLASH) operating at an average dose …

Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions

K Yogo, S Kodaira, T Kusumoto… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. FLASH radiation therapy with ultrahigh dose rates (UHDR) has the potential to
reduce damage to normal tissue while maintaining anti-tumor efficacy. However, rapid and …

Characterization of LiF: Mg, Ti thermoluminescence detectors in low-LET proton beams at ultra-high dose rates

S Motta, JB Christensen, M Togno… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. This work aims at characterizing LiF: Mg, Ti thermoluminescence detectors (TLDs)
for dosimetry of a 250 MeV proton beam delivered at ultra-high dose rates (UHDR). Possible …

A review of diamond dosimeters in advanced radiotherapy techniques

C Angelou, IS Patallo, D Doherty, F Romano… - Medical …, 2024 - Wiley Online Library
This review article synthesizes key findings from studies on the use of diamond dosimeters
in advanced radiotherapy techniques, showcasing their applications, challenges, and …

Dosimetry for radiobiological in vivo experiments at laser plasma-based proton accelerators

M Reimold, S Assenbaum, C Bernert… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. Laser plasma-based accelerators (LPAs) of protons can contribute to research of
ultra-high dose rate radiobiology as they provide pulse dose rates unprecedented at …

Towards clinical application of ultra-high dose rate radiotherapy and the FLASH effect: Challenges and current status

A Chaikh, M Édouard, C Huet, F Milliat, C Villagrasa… - Cancer …, 2024 - Elsevier
Ultra-high dose rate external beam radiotherapy (UHDR-RT) uses dose rates of several tens
to thousands of Gy/s, compared with the dose rate of the order of a few Gy/min for …

[HTML][HTML] Dose and dose rate dependence of the tissue sparing effect at ultra-high dose rate studied for proton and electron beams using the zebrafish embryo model

F Horst, E Bodenstein, M Brand, S Hans… - Radiotherapy and …, 2024 - Elsevier
Purpose A better characterization of the dependence of the tissue sparing effect at ultra-high
dose rate (UHDR) on physical beam parameters (dose, dose rate, radiation quality) would …

Consistency of Faraday cup and ionization chamber dosimetry of proton fields and the role of nuclear interactions

J Wulff, A Paul, CM Bäcker, KS Baumann… - Medical …, 2024 - Wiley Online Library
Abstract Background A Faraday cup (FC) facilitates a quite clean measurement of the proton
fluence emerging from clinical spot‐scanning nozzles with narrow pencil‐beams. The …