Epigenetics of autism spectrum disorder
MT Siu, R Weksberg - Neuroepigenomics in aging and disease, 2017 - Springer
Autism spectrum disorder (ASD), one of the most common childhood neurodevelopmental
disorders (NDDs), is diagnosed in 1 of every 68 children. ASD is incredibly heterogeneous …
disorders (NDDs), is diagnosed in 1 of every 68 children. ASD is incredibly heterogeneous …
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer
Introduction In the current era of personalized medicine, liquid biopsy has acquired a
relevant importance in patient management of advanced stage non-small cell lung cancer …
relevant importance in patient management of advanced stage non-small cell lung cancer …
A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies
Background Intra-sample cellular heterogeneity presents numerous challenges to the
identification of biomarkers in large Epigenome-Wide Association Studies (EWAS). While a …
identification of biomarkers in large Epigenome-Wide Association Studies (EWAS). While a …
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
Genetic and environmental influences interact with age and sex in shaping the human methylome
The methylome is subject to genetic and environmental effects. Their impact may depend on
sex and age, resulting in sex-and age-related physiological variation and disease …
sex and age, resulting in sex-and age-related physiological variation and disease …
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci
We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n=
166) of human fetal brain samples spanning 56–166 d post-conception, identifying> 16,000 …
166) of human fetal brain samples spanning 56–166 d post-conception, identifying> 16,000 …
DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain
DNA methylation has become increasingly recognized in the etiology of psychiatric
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …