Following skin wounding, the healing outcome can be: regeneration, repair with normal scar
tissue, repair with hypertrophic scar tissue or the formation of keloids. The role of chemical …

The mammalian hair follicle undergoes repeated bouts of regeneration orchestrated by a
variety of hair follicle stem cells. The last decade has witnessed the emergence of the …

Regenerative capacity declines throughout evolution and with age. In this study, we asked
whether metabolic programs underlying regenerative capability might be conserved across …

An outstanding mystery in biology is why some species, such as the axolotl, can regenerate
tissues whereas mammals cannot. Here, we demonstrate that rapid activation of protein …

Limb regeneration, while observed lifelong in salamanders, is restricted in post-
metamorphic Xenopus laevis frogs. Whether this loss is due to systemic factors or an …

Studies of cell fate focus on specification, but little is known about maintenance of the
differentiated state. In this study, we find that the mouse tendon cell fate requires continuous …

The majority of animal phyla have species that can regenerate. Comparing regeneration
across animals can reconstruct the molecular and cellular evolutionary history of this …

A fundamental step in regeneration is rapid growth to replace lost tissue. Cells must
generate sufficient lipids, nucleotides, and proteins to fuel rapid cell division. To define …

De novo limb regeneration after amputation is restricted in mammals to the distal digit tip.
Central to this regenerative process is the blastema, a heterogeneous population of lineage …

Vertebrate appendage regeneration requires precisely coordinated remodeling of the
transcriptional landscape to enable the growth and differentiation of new tissue, a process …