Current strategies of antiviral drug discovery for COVID-19

M Mei, X Tan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …

Autophagy: cancer's friend or foe?

SK Bhutia, S Mukhopadhyay, N Sinha, DN Das… - Advances in cancer …, 2013 - Elsevier
The functional relevance of autophagy in tumor formation and progression remains
controversial. Autophagy can promote tumor suppression during cancer initiation and …

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

K Zhu, K Dunner, DJ McConkey - Oncogene, 2010 - nature.com
The ubiquitin-proteasome and lysosome-autophagy pathways are the two major intracellular
protein degradation systems that work cooperatively to maintain homeostasis. Proteasome …

[HTML][HTML] Innovative strategies to boost photothermal therapy at mild temperature mediated by functional nanomaterials

Y Cao, Q Ren, R Hao, Z Sun - Materials & Design, 2022 - Elsevier
The last few years have witnessed explosive growth in the design and development of
various photothermal agents (PTAs) to realize phtothermal therapy (PTT) for eradicating …

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

W Xiao, J Wang, X Wang, S Cai, Y Guo, L Ye, D Li… - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis
and aggressiveness, while mechanisms regulating expression of autophagic machinery …

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

EL Kim, R Wüstenberg, A Rübsam… - Neuro …, 2010 - academic.oup.com
Glioblastoma is the most common malignant brain tumor in adults. The currently available
treatments offer only a palliative survival advantage and the need for effective treatments …

Pharmacological inhibitors of autophagy as novel cancer therapeutic agents

C Wang, Q Hu, HM Shen - Pharmacological research, 2016 - Elsevier
Autophagy is an evolutionarily conserved cellular degradative process in which intracellular
components (cellular proteins and organelles) are engulfed in autophagosomes which then …

Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis

JS Carew, CM Espitia, JA Esquivel… - Journal of Biological …, 2011 - ASBMB
Cellular stress induced by nutrient deprivation, hypoxia, and exposure to many
chemotherapeutic agents activates an evolutionarily conserved cell survival pathway termed …

What is the malignant nature of human ductal carcinoma in situ?

V Espina, LA Liotta - Nature Reviews Cancer, 2011 - nature.com
Invasive, genetically abnormal carcinoma progenitor cells have been propagated from
human and mouse breast ductal carcinoma in situ (DCIS) lesions, providing new insights …

Chiral platinum (II) complexes featuring phosphine and chloroquine ligands as cytotoxic and monofunctional DNA-binding agents

W Villarreal, L Colina-Vegas… - Inorganic …, 2015 - ACS Publications
Chiral molecules in nature are involved in many biological events; their selectivity and
specificity make them of great interest for understanding the behavior of bioactive molecules …