The relationship between the gut microbiome and host gene expression: a review
RG Nichols, ER Davenport - Human genetics, 2021 - Springer
Despite the growing knowledge surrounding host–microbiome interactions, we are just
beginning to understand how the gut microbiome influences—and is influenced by—host …
beginning to understand how the gut microbiome influences—and is influenced by—host …
Microbiota and mucosal defense in IBD: an update
EF Stange, BO Schroeder - Expert review of gastroenterology & …, 2019 - Taylor & Francis
Introduction: Inflammatory bowel diseases (IBD) are on the rise worldwide. This review
covers the current concepts of the etiology of Crohn´ s disease and ulcerative colitis by …
covers the current concepts of the etiology of Crohn´ s disease and ulcerative colitis by …
Identification of shared and disease-specific host gene–microbiome associations across human diseases using multi-omic integration
While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …
[HTML][HTML] Therapeutic interleukin-6 trans-signaling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease
Background & Aims A large unmet therapeutic need exists in inflammatory bowel disease
(IBD). Inhibition of interleukin (IL)-6 appears to be effective, but the therapeutic benefit of a …
(IBD). Inhibition of interleukin (IL)-6 appears to be effective, but the therapeutic benefit of a …
[HTML][HTML] Metabolic functions of gut microbes associate with efficacy of tumor necrosis factor antagonists in patients with inflammatory bowel diseases
Background & Aims Altered interactions between the mucosal immune system and intestinal
microbiota contribute to pathogenesis of inflammatory bowel diseases (IBD). It is not clear …
microbiota contribute to pathogenesis of inflammatory bowel diseases (IBD). It is not clear …
[HTML][HTML] DNA methylation and transcription patterns in intestinal epithelial cells from pediatric patients with inflammatory bowel diseases differentiate disease subtypes …
KJ Howell, J Kraiczy, KM Nayak, M Gasparetto, A Ross… - Gastroenterology, 2018 - Elsevier
Background & Aims We analyzed DNA methylation patterns and transcriptomes of primary
intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel …
intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel …
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis
F Hinrichsen, J Hamm, M Westermann, L Schröder… - Cell Metabolism, 2021 - cell.com
Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly
expressed in gut epithelium, contributes to immune responses, and is upregulated during …
expressed in gut epithelium, contributes to immune responses, and is upregulated during …
Big data in IBD: big progress for clinical practice
IBD is a complex multifactorial inflammatory disease of the gut driven by extrinsic and
intrinsic factors, including host genetics, the immune system, environmental factors and the …
intrinsic factors, including host genetics, the immune system, environmental factors and the …
Human retinoic acid–regulated CD161+ regulatory T cells support wound repair in intestinal mucosa
GAM Povoleri, E Nova-Lamperti, C Scottà… - Nature …, 2018 - nature.com
Repair of tissue damaged during inflammatory processes is key to the return of local
homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T …
homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T …
[HTML][HTML] Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice
Early-life antibiotic exposure perturbs the intestinal microbiota and accelerates type 1
diabetes (T1D) development in the NOD mouse model. Here, we found that maternal cecal …
diabetes (T1D) development in the NOD mouse model. Here, we found that maternal cecal …