[HTML][HTML] Small molecules containing chalcogen elements (S, Se, Te) as new warhead to fight neglected tropical diseases
A Henriquez-Figuereo, C Morán-Serradilla… - European Journal of …, 2023 - Elsevier
Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a
protozoan etiology, high incidence, and prevalence in developing countries. As a result …
protozoan etiology, high incidence, and prevalence in developing countries. As a result …
Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
Novel sulfonyl thiazolyl-hydrazone derivatives as EGFR inhibitors: Design, synthesis, biological evaluation and molecular docking studies
TA Farghaly, EMH Abbas, AM Al-Soliemy, R Sabour… - Bioorganic …, 2022 - Elsevier
New hydrazonoyl-sulfonylthiazoles were designed and synthesized as EGFR inhibitors. The
new sulfonylthiazole derivatives were assessed in vitro to measure their effect on EGFR …
new sulfonylthiazole derivatives were assessed in vitro to measure their effect on EGFR …
Synthesis of a new series of pyrazolo [1, 5-a] pyrimidines as CDK2 inhibitors and anti-leukemia
Based on the structural study of previously known CDK2 inhibitors, a new series of pyrazolo
[1, 5-a] pyrimidine derivatives was designed and synthesized. The target compounds were …
[1, 5-a] pyrimidine derivatives was designed and synthesized. The target compounds were …
Anti-viral activity of thiazole derivatives: An updated patent review
TA Farghaly, AMR Alsaedi, NA Alenazi… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Several viral infections cause life-threatening consequences in humans, making
them the most serious public health concerns. Despite the fact that several antiviral …
them the most serious public health concerns. Despite the fact that several antiviral …
Ligand-Based Virtual Screening for Discovery of Indole Derivatives as Potent DNA Gyrase ATPase Inhibitors Active against Mycobacterium tuberculosis and Hit …
B Pakamwong, P Thongdee, B Kamsri… - Journal of Chemical …, 2024 - ACS Publications
Mycobacterium tuberculosis is the single most important global infectious disease killer and
a World Health Organization critical priority pathogen for development of new antimicrobials …
a World Health Organization critical priority pathogen for development of new antimicrobials …
Multicomponent synthesis of fluorescent thiazole–indole hybrids and thiazole-based novel polymers
P Bhaumick, R Kumar, SS Acharya… - The Journal of …, 2022 - ACS Publications
Herein, we report an efficient multicomponent reaction for the synthesis of trisubstituted
thiazoles involving a one-pot C–C, C–N, and C–S bond-forming process from the readily …
thiazoles involving a one-pot C–C, C–N, and C–S bond-forming process from the readily …
Novel thiazole derivatives incorporating phenyl sulphonyl moiety as potent BRAFV600E kinase inhibitors targeting melanoma
AY Khormi, TA Farghaly, A Bayazeed, YO Al-Ghamdi… - RSC …, 2022 - pubs.rsc.org
Novel thiazole derivatives possessing phenyl sulfonyl moiety were designed and
synthesized as B-RAFV600E kinase inhibitors based on the clinically-approved anticancer …
synthesized as B-RAFV600E kinase inhibitors based on the clinically-approved anticancer …
Exploring a novel thiazole derivatives hybrid with fluorinated-indenoquinoxaline as dual inhibitors targeting VEGFR2/AKT and apoptosis inducers against …
Hepatocellular carcinoma (HCC) ranks as the third most prevalent reason for cancer-related
death on a global scale. Tyrosine kinase inhibitors (TKIs) continue to be the primary …
death on a global scale. Tyrosine kinase inhibitors (TKIs) continue to be the primary …
Design, Synthesis, antimicrobial screening and molecular modeling of novel 6, 7 dimethylquinoxalin-2 (1H)-one and thiazole derivatives targeting DNA gyrase …
RM Alqurashi, TA Farghaly, R Sabour… - Bioorganic …, 2023 - Elsevier
Abstract New 6, 7-dimethylquinoxalin-2 (1H)-one and hydrazineylidene thiazol-4-one
derivatives were synthesized, and evaluated for their in vitro antimicrobial activity. The …
derivatives were synthesized, and evaluated for their in vitro antimicrobial activity. The …