[HTML][HTML] The world goes bats: living longer and tolerating viruses

V Gorbunova, A Seluanov, BK Kennedy - Cell Metabolism, 2020 - cell.com
For centuries, people believed that bats possessed sinister powers. Bats are thought to be
ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most …

Alternative animal models of aging research

S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases

M Ahn, VCW Chen, P Rozario, WL Ng, P San Kong… - Cell, 2023 - cell.com
Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …

Near‐Infrared II Light‐Triggered Robust Carbon Radical Generation for Combined Photothermal and Thermodynamic Therapy of Hypoxic Tumors

X Liu, Y Yang, M Ling, R Sun, M Zhu… - Advanced Functional …, 2021 - Wiley Online Library
Tumor hypoxia is a major cause of failure in cancer therapy, and there is almost no
efficacious treatment for hypoxic tumors. Herein, an azo‐containing polymer (P2) is …

Host–Pathogen interactions influencing zoonotic spillover potential and transmission in humans

B Escudero-Pérez, A Lalande, C Mathieu, P Lawrence - Viruses, 2023 - mdpi.com
Emerging infectious diseases of zoonotic origin are an ever-increasing public health risk
and economic burden. The factors that determine if and when an animal virus is able to spill …

[PDF][PDF] COVID-19 is possibly a consequence of the anthropogenic biodiversity crisis and climate changes

HF Lorentzen, T Benfield, S Stisen… - Danish medical …, 2020 - portal.findresearcher.sdu.dk
Climate change has set the agenda since the UN Climate Change Conference (COP-25) but
has nearly disappeared from public debate following the outbreak of the Coronavirus …

Acute and chronic impacts of heat stress on planetary health

V Sampath, O Shalakhti, E Veidis, JAI Efobi… - Allergy, 2023 - Wiley Online Library
Heat waves are increasing in intensity, frequency, and duration causing significant heat
stress in all living organisms. Heat stress has multiple negative effects on plants affecting …

Viral evolution shaped by host proteostasis networks

J Yoon, JE Patrick, CB Ogbunugafor… - Annual Review of …, 2023 - annualreviews.org
Understanding the factors that shape viral evolution is critical for developing effective
antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One …

Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies

TG Heck, MS Ludwig, MN Frizzo… - Clinical …, 2020 - portlandpress.com
The major risk factors to fatal outcome in COVID-19 patients, ie, elderliness and pre-existing
metabolic and cardiovascular diseases (CVD), share in common the characteristic of being …

Genomic and biological variation in bat IFNs: An antiviral treatment approach

L AL‐Eitan, A Mihyar, L Zhang, P Bisht… - Reviews in Medical …, 2024 - Wiley Online Library
Bat‐borne viruses have attracted considerable research, especially in relation to the Covid‐
19 pandemic. Although bats can carry multiple zoonotic viruses that are lethal to many …