Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by
structural and functional alterations of the heart. Aims: The purpose of this narrative review is …

The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

We have developed a new technique for proximity-dependent labeling of proteins in
eukaryotic cells. Named BioID for proximity-dependent biotin identification, this approach is …

Dilated cardiomyopathy (DCM) is characterized by left ventricular dilatation and,
consecutively, contractile dysfunction. The causes of DCM are heterogeneous. DCM often …

The muscular dystrophies are inherited myogenic disorders characterised by progressive
muscle wasting and weakness of variable distribution and severity. They can be subdivided …

Emery‐Dreifuss muscular dystrophy (EDMD) is a rare muscular dystrophy, but is particularly
important to diagnose due to frequent life‐threatening cardiac complications. EDMD …

Mutations in genes encoding the intermediate filament nuclear lamins and associated
proteins cause a wide spectrum of diseases sometimes called “laminopathies.” Diseases …

Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear …

Objectives: We examined the prevalence, genotype-phenotype correlation, and natural
history of lamin A/C gene (LMNA) mutations in subjects with dilated cardiomyopathy (DCM) …

It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …