mTOR signaling in renal ion transport
A Adella, JHF de Baaij - Acta Physiologica, 2023 - Wiley Online Library
The mammalian target of rapamycin (mTOR) signaling pathway is crucial in maintaining cell
growth and metabolism. The mTOR protein kinase constitutes the catalytic subunit of two …
growth and metabolism. The mTOR protein kinase constitutes the catalytic subunit of two …
[HTML][HTML] Oxidative Stress in Kidney Injury and Hypertension
WJ Arendshorst, AE Vendrov, N Kumar, SK Ganesh… - Antioxidants, 2024 - mdpi.com
Hypertension (HTN) is a major contributor to kidney damage, leading to conditions such as
nephrosclerosis and hypertensive nephropathy, significant causes of chronic kidney disease …
nephrosclerosis and hypertensive nephropathy, significant causes of chronic kidney disease …
Male kidney-specific BMAL1 knockout mice are protected from K+-deficient, high-salt diet-induced blood pressure increases
GR Crislip, HM Costello, A Juffre… - American Journal …, 2023 - journals.physiology.org
The circadian clock protein basic helix-loop-helix aryl hydrocarbon receptor nuclear
translocator-like protein 1 (BMAL1) is a transcription factor that impacts kidney function …
translocator-like protein 1 (BMAL1) is a transcription factor that impacts kidney function …
Caloric restriction reduces proteinuria in male rats with established nephropathy
JWA Sijbesma, A van Waarde, A Klooster… - Physiological …, 2024 - Wiley Online Library
Reducing proteinuria is a crucial approach in preventing kidney function loss. Previous
preclinical studies indicated that caloric restriction (CR) imposed at a young age protects …
preclinical studies indicated that caloric restriction (CR) imposed at a young age protects …
Sex hormones, sex chromosomes, and microbiota: identification of Akkermansia muciniphila as an estrogen-responsive bacterium
A Sakamuri, P Bardhan, R Tummala… - Microbiota and …, 2023 - mah.bioscientifica.com
Microbiota composition is known to be linked to sex. However, separating sex hormones
and sex chromosome roles in gut microbial diversity is yet to be determined. To investigate …
and sex chromosome roles in gut microbial diversity is yet to be determined. To investigate …
T-cells regulate albuminuria but not hypertension, renal histology, or the medullary transcriptome in the Dahl SSCD247+/+ rat
A Dayton, RN Almutlaq, S Guntipally… - American Journal …, 2024 - journals.physiology.org
In the current study, we took advantage of the loss of protection from hypertension in
SSCD247−/− rats to characterize the pathological effects of renal T-cells in isolation from the …
SSCD247−/− rats to characterize the pathological effects of renal T-cells in isolation from the …
Metabolic responses of normal rat kidneys to a high salt intake
S Shimada, BR Hoffmann, C Yang, T Kurth… - Function, 2023 - academic.oup.com
In this study, novel methods were developed, which allowed continuous (24/7)
measurement of arterial blood pressure and renal blood flow in freely moving rats and the …
measurement of arterial blood pressure and renal blood flow in freely moving rats and the …