[HTML][HTML] Vero cell upstream bioprocess development for the production of viral vectors and vaccines

S Kiesslich, AA Kamen - Biotechnology advances, 2020 - Elsevier
The Vero cell line is considered the most used continuous cell line for the production of viral
vectors and vaccines. Historically, it is the first cell line that was approved by the WHO for the …

Racing to immunity: journey to a COVID‐19 vaccine and lessons for the future

E Calvo Fernández, LY Zhu - British journal of clinical …, 2021 - Wiley Online Library
SARS‐CoV‐2 is the novel coronavirus behind the COVID‐19 pandemic. Since its
emergence, the global scientific community has mobilized to study this virus, and an …

Atypical cyclins: the extended family portrait

E Quandt, MPC Ribeiro, J Clotet - Cellular and Molecular Life Sciences, 2020 - Springer
Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic
workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by …

Mammalian neuraminidases in immune-mediated diseases: mucins and beyond

EP Lillehoj, IG Luzina, SP Atamas - Frontiers in immunology, 2022 - frontiersin.org
Mammalian neuraminidases (NEUs), also known as sialidases, are enzymes that cleave off
the terminal neuraminic, or sialic, acid resides from the carbohydrate moieties of glycolipids …

The effect of inactivated SARS-CoV-2 vaccines on TRAB in graves' disease

LH Huang, ZR Jiang, JX Zhou, YP Chen… - Frontiers in …, 2022 - frontiersin.org
Background The ongoing coronavirus disease 2019 (COVID-19) pandemic has forced the
development of vaccines. Reports have suggested that vaccines play a role in inducing …

Host receptors: the key to establishing cells with broad viral tropism for vaccine production

X Dai, X Zhang, K Ostrikov… - Critical reviews in …, 2020 - Taylor & Francis
Cell culture-based vaccine technology is a flexible and convenient approach for vaccine
production that requires adaptation of the vaccine strains to the new cells. Driven by the …

Development and evaluation of an Ebola virus glycoprotein mucin-like domain replacement system as a new dendritic cell-targeting vaccine approach against HIV-1

Z Ao, L Wang, H Azizi, TA Olukitibi, G Kobinger… - Journal of …, 2021 - Am Soc Microbiol
The development of efficient vaccine approaches against HIV infection remains challenging
in the vaccine field. Here, we developed an Ebola virus envelope glycoprotein (EboGP) …

Orchestrated efforts on host network hijacking: Processes governing virus replication

X Dai, O Hakizimana, X Zhang, AC Kaushik, J Zhang - Virulence, 2020 - Taylor & Francis
With the high pervasiveness of viral diseases, the battle against viruses has never ceased.
Here we discuss five cellular processes, namely “autophagy”,“programmed cell …

G-protein-coupled receptor and ion channel genes used by influenza virus for replication

N Orr-Burks, J Murray, KV Todd, A Bakre… - Journal of …, 2021 - Am Soc Microbiol
Influenza virus causes epidemics and sporadic pandemics resulting in morbidity, mortality,
and economic losses. Influenza viruses require host genes to replicate. RNA interference …

Repurposing probenecid to inhibit SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) replication

RA Tripp, DE Martin - Viruses, 2022 - mdpi.com
Viral replication and transmissibility are the principal causes of endemic and pandemic
disease threats. There remains a need for broad-spectrum antiviral agents. The most …