Phenotypic features of cancer cachexia‐related loss of skeletal muscle mass and function: lessons from human and animal studies

A Martin, D Freyssenet - Journal of cachexia, sarcopenia and …, 2021 - Wiley Online Library
Cancer cachexia is a complex multi‐organ catabolic syndrome that reduces mobility,
increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of …

Metastasis and cachexia: alongside in clinics, but not so in animal models

R Tomasin, ACBM Martin… - Journal of cachexia …, 2019 - Wiley Online Library
Cancer cachexia is a paraneoplastic syndrome characterized by lean mass wasting (with or
without fat mass decrease), culminating in involuntary weight loss, which is the key clinical …

Fenofibrate prevents skeletal muscle loss in mice with lung cancer

MD Goncalves, SK Hwang, C Pauli… - Proceedings of the …, 2018 - National Acad Sciences
The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by
the catabolism of stored nutrients in skeletal muscle and adipose tissue that is particularly …

Circulating miR‐203 derived from metastatic tissues promotes myopenia in colorectal cancer patients

Y Okugawa, Y Toiyama, K Hur… - Journal of cachexia …, 2019 - Wiley Online Library
Background Sarcopenia frequently occurs in metastatic cancer patients. Emerging evidence
has revealed that various secretory products from metastatic tumours can influence host …

Epidemiology, risk factors and impact of cachexia on patient outcome: Results from the Japanese Lung Cancer Registry Study

T Shukuya, K Takahashi, Y Shintani… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Cancer cachexia is a syndrome that does not fully recover with nutritional
support and causes appetite loss and body weight loss. It worsens a patient's quality of life …

Tumour‐derived transforming growth factor‐β signalling contributes to fibrosis in patients with cancer cachexia

JDCC Lima, E Simoes, G de Castro… - Journal of cachexia …, 2019 - Wiley Online Library
Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The
tumour micro‐environment contributes to systemic inflammation and increased oxidative …

Body composition measured by computed tomography is associated with colorectal cancer survival, also in early-stage disease

M Shirdel, F Andersson, R Myte, J Axelsson… - Acta …, 2020 - Taylor & Francis
Background: Cachexia and sarcopenia are associated with poor survival after colorectal
cancer (CRC) diagnosis. Computed tomography (CT) can be used to measure aspects of …

Inhibition of epidermal growth factor receptor suppresses parathyroid hormone‐related protein expression in tumours and ameliorates cancer‐associated cachexia

BZC Weber, S Agca, A Domaniku… - Journal of cachexia …, 2022 - Wiley Online Library
Background Lung cancer is the primary cause of cancer deaths worldwide. Activation of
epidermal growth factor receptor (EGFR) leads to lung cancer progression and poor …

Preoperative pectoralis muscle index predicts distant metastasis-free survival in breast cancer patients

W Huang, M Zhang, W Wang, Q Jia, J Yuan… - Frontiers in …, 2022 - frontiersin.org
Background Breast cancer is one of the most commonly diagnosed cancers, and the fourth
leading cause of cancer deaths in females worldwide. Sarcopenia is related to adverse …

Cancer‐and chemotherapy‐induced musculoskeletal degradation

KM Sturgeon, KM Mathis, CJ Rogers, KH Schmitz… - JBMR …, 2019 - Wiley Online Library
Mobility in advanced cancer patients is a major health care concern and is often lost in
advanced metastatic cancers. Erosion of mobility is a major component in determining …