Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …

The escalating issues of energy crises and environmental pollution have drawn increasing
attention for photocatalysis as a green and sustainable solution. In this context, the …

Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but
is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot …

Taste-masking of drugs, particularly to produce formulations for pediatric patients, can be
challenging and require complex manufacturing approaches. The objective of this study was …

This study aimed to investigate the efficacy of conventional dry granulation (slugging) and
twin-screw melt granulation (TSMG) as downstream processing methods to enhance the …

Abstract Interest in Twin Screw Melt Granulation (TSMG) processes is rapidly increasing,
along with the search for suitable excipients. This study aims to optimize the TSMG process …

Background/Objectives: This study evaluates the efficacy of twin screw melt granulation
(TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and …

Hot-melt extrusion (HME) technology is rapidly growing in the pharmaceutical industry over
recent years to provide the industry's most groundbreaking drug delivery technologies …

Twin screw granulation (TSG) has recently been emerged as a novel approach for the
continuous wet granulation of fine particles (ie, powders) in the pharmaceutical industry. The …

Twin-screw melt granulation (TSMG) relies on the dispersive and distributive mixing at the
kneading zone for granule growth to happen highlighting the critical role played by the …