S Lee, J Rauch, W Kolch - International journal of molecular sciences, 2020 - mdpi.com
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
ZF Lim, PC Ma - Journal of hematology & oncology, 2019 - Springer
The biggest hurdle to targeted cancer therapy is the inevitable emergence of drug resistance. Tumor cells employ different mechanisms to resist the targeting agent. Most …
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
A Zaman, W Wu, TG Bivona - Cancers, 2019 - mdpi.com
Identifying recurrent somatic genetic alterations of, and dependency on, the kinase BRAF has enabled a “precision medicine” paradigm to diagnose and treat BRAF-driven tumors …
S Gross, R Rahal, N Stransky… - The Journal of …, 2015 - Am Soc Clin Investig
Kinase inhibitors have played an increasingly prominent role in the treatment of cancer and other diseases. Currently, more than 25 oncology drugs that target kinases have been …
Q Li, Z Li, T Luo, H Shi - Molecular biomedicine, 2022 - Springer
Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
H Patel, N Yacoub, R Mishra, A White, L Yuan… - Cancers, 2020 - mdpi.com
Melanoma is the most lethal form of skin cancer. Melanoma is usually curable with surgery if detected early, however, treatment options for patients with metastatic melanoma are limited …
SA Luebker, SA Koepsell - Frontiers in oncology, 2019 - frontiersin.org
BRAF inhibitor therapy may provide profound initial tumor regression in metastatic melanoma with BRAF V600 mutations, but treatment resistance often leads to disease …
UA Germann, BF Furey, W Markland, RR Hoover… - Molecular cancer …, 2017 - AACR
Aberrant activation of signaling through the RAS–RAF–MEK–ERK (MAPK) pathway is implicated in numerous cancers, making it an attractive therapeutic target. Although BRAF …