Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …

The biggest hurdle to targeted cancer therapy is the inevitable emergence of drug
resistance. Tumor cells employ different mechanisms to resist the targeting agent. Most …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Identifying recurrent somatic genetic alterations of, and dependency on, the kinase BRAF
has enabled a “precision medicine” paradigm to diagnose and treat BRAF-driven tumors …

Kinase inhibitors have played an increasingly prominent role in the treatment of cancer and
other diseases. Currently, more than 25 oncology drugs that target kinases have been …

Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …

Melanoma is the most lethal form of skin cancer. Melanoma is usually curable with surgery if
detected early, however, treatment options for patients with metastatic melanoma are limited …

BRAF inhibitor therapy may provide profound initial tumor regression in metastatic
melanoma with BRAF V600 mutations, but treatment resistance often leads to disease …

Aberrant activation of signaling through the RAS–RAF–MEK–ERK (MAPK) pathway is
implicated in numerous cancers, making it an attractive therapeutic target. Although BRAF …