Historically women were frequently excluded from clinical trials and drug usage to protect
unborn babies from potential harm. As a consequence, the impact of sex and gender on …

Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …

Background Genetic and lifestyle factors are associated with cancer risk. We investigated
the benefits of adhering to lifestyle advice by the World Cancer Research Fund (WCRF) with …

Background The genetic architectures of colorectal cancer are distinct across different
populations. To date, the majority of polygenic risk scores (PRSs) are derived from …

Background Lifestyle and longevity genes have different and important roles in the human
lifespan; however, the association between a healthy lifestyle in late-life and life expectancy …

Background The combined effects of ambient air pollution, lifestyle, and genetic
predisposition on incident Type 2 Diabetes (T2D) have not been well documented. Methods …

Background Understanding the temporal trends in the epidemiology of colorectal cancer
(CRC) and early-onset CRC (EOCRC) in China is essential for policymakers to develop …

Background There is a growing body of evidence on the effect of the local environment
exposure on cancer susceptibility. Nonetheless, several of the associations remain …

Importance Genetic and lifestyle factors are related to thyroid cancer (TC). Whether a healthy
lifestyle is associated with TC and could attenuate the influence of genetic variants in TC …

Background Menopausal hormone therapy (MHT), a common treatment to relieve symptoms
of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC …