Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various
mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, the reduced …

Ion channels are transmembrane proteins ubiquitously expressed in all cells that control
various ions (eg Na+, K+, Ca 2+ and Cl-etc) crossing cellular plasma membrane, which play …

The regulation of reactive oxygen species (ROS)-sensitive calcium (Ca2+) channels is of
great significance in the treatment of tumors. Here, a simple ROS generation system is …

Ions are the cornerstones of various biological functions and have been widely used for
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …

Objective. In periodontitis, excessive oxidative stress combined with subsequent apoptosis
and cell death further exacerbated periodontium destruction. TRPA1, an important transient …

Reactive oxygen species (ROS) play an important role in regulating various physiological
functions by activating specific ion channels to mediate cell growth, proliferation …

The gated state of anion channels is involved in the regulation of proliferation and migration
of tumors. Specific regulators are urgently needed for efficacious cancer ablation. For this …

Immunogenic cell death (ICD) induced by calcium ion (Ca2+) overload has attracted
significant attention owing to its ability to activate the immune system and generate durable …

Transient receptor potential (TRP) channels, first identified in Drosophila in 1969, are
multifunctional ion channels expressed in various cell types. Structurally, TRP channels …

Transient-receptor potential (TRP) channels comprise a diverse family of ion channels,
which play important roles in regulation of intracellular calcium. Emerging evidence has …