Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?

H Hou, D Chen, K Zhang, W Zhang, T Liu, S Wang… - Cancer Letters, 2022 - Elsevier
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. It involves the complex interactions between genetic …

[HTML][HTML] Gut microbiota dysbiosis, oxidative stress, inflammation, and epigenetic alterations in metabolic diseases

H Mostafavi Abdolmaleky, JR Zhou - Antioxidants, 2024 - mdpi.com
Gut dysbiosis, resulting from an imbalance in the gut microbiome, can induce excessive
production of reactive oxygen species (ROS), leading to inflammation, DNA damage …

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

CN Spencer, JL McQuade, V Gopalakrishnan… - Science, 2021 - science.org
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in
cancer, but the effect of diet and supplements on this interaction is not well studied. We …

[HTML][HTML] Gut bacterial metabolism contributes to host global purine homeostasis

K Kasahara, RL Kerby, Q Zhang, M Pradhan… - Cell host & …, 2023 - cell.com
The microbes and microbial pathways that influence host inflammatory disease progression
remain largely undefined. Here, we show that variation in atherosclerosis burden is partially …

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic

J Sun, S Chen, D Zang, H Sun… - … journal of oncology, 2024 - spandidos-publications.com
Cancer is one of the leading causes of mortality worldwide. The etiology of cancer has not
been fully elucidated yet, and further enhancements are necessary to optimize therapeutic …

Networks and graphs discovery in metabolomics data analysis and interpretation

A Amara, C Frainay, F Jourdan, T Naake… - Frontiers in Molecular …, 2022 - frontiersin.org
Both targeted and untargeted mass spectrometry-based metabolomics approaches are used
to understand the metabolic processes taking place in various organisms, from prokaryotes …

[HTML][HTML] The gut-lung axis in severe acute Pancreatitis-associated lung injury: The protection by the gut microbiota through short-chain fatty acids

Z Wang, J Liu, F Li, Y Luo, P Ge, Y Zhang… - Pharmacological …, 2022 - Elsevier
The role of gut microbiota in regulating the intestinal homeostasis, as well as the
pathogenesis of severe acute pancreatitis-associated lung injury (PALI) is widely …

Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia

H Xu, F Fang, K Wu, J Song, Y Li, X Lu, J Liu, L Zhou… - Microbiome, 2023 - Springer
Background Diet-induced dyslipidemia is linked to the gut microbiota, but the causality of
microbiota-host interaction affecting lipid metabolism remains controversial. Here, the …

Health benefits of dietary fiber for the management of inflammatory bowel disease

K Yusuf, S Saha, S Umar - Biomedicines, 2022 - mdpi.com
Crohn's disease (CD) and ulcerative colitis (UC), two components of inflammatory bowel
disease (IBD), are painful conditions that affect children and adults. Despite substantial …

[HTML][HTML] Designing healthier bread through the lens of the gut microbiota

Y Wang, C Jian, A Salonen, M Dong, Z Yang - Trends in Food Science & …, 2023 - Elsevier
Background Food systems worldwide have become industrialized over the past century with
impacts on diets, nutrition and health. The trade-offs between affordability and higher-quality …