Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …

The formation of membraneless organelles can be a proteotoxic stress control mechanism
that locally condenses a set of components capable of mediating protein degradation …

Developmental systems integrate inputs of variation from different origins into the
observable variation of the resulting phenotype. Different components of phenotypic …

Bistable autoactivation has been proposed as a mechanism for cells to adopt binary fates
during embryonic development. However, it is unclear whether the autoactivating modules …

Flying insects have invaded all the aerial space on Earth and this astonishing radiation
could not have been possible without a remarkable morphological diversification of their …

Nonsense-mediated decay (NMD) is a translation-dependent RNA quality control
mechanism that occurs in the cytoplasm. However, it is unknown how NMD regulates the …

Hox genes encode transcription factors that play an important role in establishing the basic
body plan of animals. In Drosophila, Antennapedia is one of the five genes that make up the …

Background Family members who have children with Severe Mental Disorder under their
care have a hard impact on them as they are faced with the task of attending to their …

Recently, advances in fluorescent in-situ hybridization techniques and in imaging
technology have enabled visualization and counting of individual RNA molecules in single …

The design of protein interaction interfaces is a cornerstone of synthetic biology, where they
can be used to promote the association of protein subunits into active molecular complexes …