Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer
Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
Therapeutic application of natural products: NAD+ metabolism as potential target
C Guo, Q Huang, Y Wang, Y Yao, J Li, J Chen, M Wu… - Phytomedicine, 2023 - Elsevier
Background Nicotinamide adenine dinucleotide (NAD+) metabolism is involved in the entire
physiopathological process and is critical to human health. Long-term imbalance in NAD+ …
physiopathological process and is critical to human health. Long-term imbalance in NAD+ …
Human RecQ helicases in DNA double-strand break repair
RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …
animals. These helicases play important roles in multiple cellular functions, including DNA …
Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases
Z Pan, H Dong, N Huang, J Fang - Frontiers in Physiology, 2022 - frontiersin.org
Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone
deacetylases, comprising seven members SIRT1-SIRT7. Sirtuins have been extensively …
deacetylases, comprising seven members SIRT1-SIRT7. Sirtuins have been extensively …
[HTML][HTML] Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence
L Averdunk, MA Huetzen, D Moreno-Andrés, R Kalb… - Genetics in …, 2023 - Elsevier
Abstract Purpose Rothmund-Thomson syndrome (RTS) is characterized by poikiloderma,
sparse hair, small stature, skeletal defects, cancer, and cataracts, resembling features of …
sparse hair, small stature, skeletal defects, cancer, and cataracts, resembling features of …
Nuclear factor Nrf2 promotes glycosidase OGG1 expression by activating the AKT pathway to enhance leukemia cell resistance to cytarabine
Q Shang, C Pan, X Zhang, T Yang, T Hu… - Journal of Biological …, 2023 - ASBMB
Chemotherapy resistance is the dominant challenge in the treatment of acute myeloid
leukemia (AML). Nuclear factor E2–related factor 2 (Nrf2) exerts a vital function in drug …
leukemia (AML). Nuclear factor E2–related factor 2 (Nrf2) exerts a vital function in drug …
[HTML][HTML] Skin abnormalities in disorders with DNA repair defects, premature aging, and mitochondrial dysfunction
Defects in DNA repair pathways and alterations of mitochondrial energy metabolism have
been reported in multiple skin disorders. More than 10% of patients with primary …
been reported in multiple skin disorders. More than 10% of patients with primary …
Role and regulation of the RECQL4 family during genomic integrity maintenance
TT Luong, KA Bernstein - Genes, 2021 - mdpi.com
RECQL4 is a member of the evolutionarily conserved RecQ family of 3'to 5'DNA helicases.
RECQL4 is critical for maintaining genomic stability through its functions in DNA repair …
RECQL4 is critical for maintaining genomic stability through its functions in DNA repair …
DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks
Non-homologous end joining (NHEJ) is the major pathway that mediates the repair of DNA
double-strand breaks (DSBs) generated by ionizing radiation (IR). Previously, the DNA …
double-strand breaks (DSBs) generated by ionizing radiation (IR). Previously, the DNA …
[PDF][PDF] UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair
The human RecQ DNA helicase, RECQL4, plays a pivotal role in maintaining genomic
stability by regulating the DNA double-s trand breaks (DSBs) repair pathway, and is, thus …
stability by regulating the DNA double-s trand breaks (DSBs) repair pathway, and is, thus …