Development and functions of the choroid plexus–cerebrospinal fluid system
The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has
accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates …
accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates …
Emergence and developmental roles of the cerebrospinal fluid system
RM Fame, MK Lehtinen - Developmental cell, 2020 - cell.com
We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain
function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS …
function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS …
[HTML][HTML] A cellular and spatial map of the choroid plexus across brain ventricles and ages
The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and
forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP …
forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP …
Choroid plexus pathophysiology
Y Courtney, A Hochstetler… - Annual Review of …, 2024 - annualreviews.org
This review examines the crucial roles of the choroid plexus (ChP) in central nervous system
(CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic …
(CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic …
SJPedPanel: a pan-cancer gene panel for childhood malignancies to enhance cancer monitoring and early detection
P Kolekar, V Balagopal, L Dong, Y Liu… - Clinical Cancer …, 2024 - aacrjournals.org
Purpose: The purpose of the study was to design a pan-cancer gene panel for childhood
malignancies and validate it using clinically characterized patient samples. Experimental …
malignancies and validate it using clinically characterized patient samples. Experimental …
DDX3X suppresses the susceptibility of hindbrain lineages to medulloblastoma
DM Patmore, A Jassim, E Nathan, RJ Gilbertson… - Developmental cell, 2020 - cell.com
Summary DEAD-Box Helicase 3 X-Linked (DDX3X) is frequently mutated in the Wingless
(WNT) and Sonic hedghog (SHH) subtypes of medulloblastoma—the commonest malignant …
(WNT) and Sonic hedghog (SHH) subtypes of medulloblastoma—the commonest malignant …
The genetic landscape of choroid plexus tumors in children and adults
C Thomas, P Soschinski, M Zwaig… - Neuro …, 2021 - academic.oup.com
Abstract Background Choroid plexus tumors (CPTs) are intraventricular brain tumors
predominantly arising in children but also affecting adults. In most cases, driver mutations …
predominantly arising in children but also affecting adults. In most cases, driver mutations …
EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart
Stalled DNA replication fork restart after stress as orchestrated by ATR kinase, BLM
helicase, and structure-specific nucleases enables replication, cell survival, and genome …
helicase, and structure-specific nucleases enables replication, cell survival, and genome …
[HTML][HTML] The NF–Y splicing signature controls hybrid EMT and ECM-related pathways to promote aggressiveness of colon cancer
Aberrant splicing events are associated with colorectal cancer (CRC) and provide new
opportunities for tumor diagnosis and treatment. The expression of the splice variants of NF …
opportunities for tumor diagnosis and treatment. The expression of the splice variants of NF …
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer
S Duffy, HK Fam, YK Wang, EB Styles… - Proceedings of the …, 2016 - National Acad Sciences
Somatic copy number amplification and gene overexpression are common features of many
cancers. To determine the role of gene overexpression on chromosome instability (CIN), we …
cancers. To determine the role of gene overexpression on chromosome instability (CIN), we …