Bioengineered in vitro models of the kidney offer unprecedented opportunities to better
mimic the in vivo microenvironment. Kidney-on-a-chip technology reproduces 2D or 3D …

Epithelium and endothelium, occupying a significant proportion of cells in the human body,
play a crucial role in maintaining organs' normal structure and function. Various methods …

Much effort has been expended in emulating the kidney's glomerular unit because of its
limitless potential in the field of drug screening and nephrotoxicity testing in clinics. Herein …

Abstract Ischemia/reperfusion (I/R) is an important inducer of acute kidney injury (AKI), and
triggers the generation of reactive oxygen species (ROS) and the expression of matrix …

The glomerular basement membrane (GBM) is an important component of the kidney
filtration barrier. The ability to evaluate the molecular transport properties of the GBM and …

Objective Diabetic nephropathy is one of the most important microvascular complications of
diabetes, which mainly refers to glomerular capillary sclerosis. Podocytes are an important …

Proteinuria, the presence of high molecular weight proteins in the urine, is a primary
indicator of chronic kidney disease. Proteinuria results from increased molecular …

Renal ischemia/reperfusion injury (RIRI) is an inevitable complication following kidney
transplantation surgery, accompanied by the generation of a large amount of free radicals. A …

Organ decellularization creates cell-free, collagen-based extracellular matrices that can be
used as scaffolds for tissue engineering applications. This technique has recently gained …

The integrity of the barrier between blood and the selective filtrate of solutes is important for
homeostasis and its disruption contributes to many diseases. Microphysiological systems …