Cancer of the esophagus exists in 2 main forms with different etiological and pathological
characteristics—squamous cell carcinoma (SCC) and adenocarcinoma (ADC). This review …

As a tumour suppressor gene, the inactivation of p53 induces the development of numerous
human cancers. Mutations of p53 have been implicated in the pathogenesis of head and …

We describe and discuss a method of protein extraction for Western blot analysis from
formalin-fixed, paraffin-embedded tissue sections. From 5-mm2 50-μm-thick tissue sections …

Background: Recent basic discoveries about the biological significance of nuclear and cell-
surface marker proteins have opened new areas of research into head and neck cancer …

BACKGROUND p53 gene mutation and p53 protein accumulation are common in human
cancer. However, their clinical significance is controversial and p53 accumulation may not …

Background. Mutations of the p53 gene belong to the most common genetic alterations in
human cancer that have been implicated in tumorigenesis and tumor progression. Although …

BACKGROUND Heat shock proteins (HSPs) first were defined as proteins induced by heat
shock and other environmental and pathophysiologic stresses and are implicated in protein …

BACKGROUND The ability to predict biologic behavior and treatment responsiveness would
be a valuable asset in the multimodality approach to esophageal carcinoma. The authors …

Background. The p53 gene product is known to regulate cell growth and proliferation.
Whereas the wild‐type p53 protein suppresses cell growth, the mutated p53 protein acts as …

The subjects in this study consisted of 40 preoperative untreated esophageal squamous cell
carcinoma patients. While p53 did not significantly correlate with the clinicopathological …