The hallmarks of aging constitute an interconnected network of basic mechanisms that
modulate aging and can be modulated by lifestyle factors, including dietary strategies. This …

Mitochondrial diseases disrupt cellular energy production and are among the most complex
group of inherited genetic disorders. Affecting approximately 1 in 5000 live births, they are …

Mitochondria are organelles that provide energy to cells through ATP production.
Mitochondrial dysfunction has long been postulated to mediate cellular declines that drive …

Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial
electron transport chain complex I. It has been hypothesized that normal aging and age …

In this review, we detail the current state of application of gene therapy to primary
mitochondrial disorders (PMDs). Recombinant adeno‐associated virus‐based (rAAV) gene …

Compelling epidemiologic data support the critical role of dietary fructose in the epidemic of
obesity, metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). The metabolic …

The mitochondrial unfolded protein response (UPRmt) is a stress response mediated by the
expression of genes such as chaperones, proteases, and mitokines to maintain …

Prolonged lifespan and improved health in late adulthood can be achieved by partial
inhibition of mitochondrial proteins in yeast, worms, fruit flies, and mice. Upregulation of the …

Our study revisits the role of cardiac mitochondrial adjustments during the progression of
type 2 diabetes mellitus (T2DM), while considering age and sex as potential confounding …

SURF1 (surfeit locus protein 1)-related Leigh syndrome is an early-onset neurodegenerative
disorder, characterized by reduction in complex IV activity, resulting in disrupted …