Epilepsy, one of the most severe neurological diseases, is characterized by abrupt recurrent
seizures. Despite great progress in the development of antiseizure drugs (ASDs) based on …

Electrical brain stimulation has become an essential treatment option for more than one third
of epilepsy patients who are resistant to pharmacological therapy and are not candidates for …

Epilepsy has been classically seen as a brain disorder resulting from abnormally enhanced
neuronal excitability and synchronization. Although it has been described since antiquity …

Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …

Secondary generalized seizure (sGS) is a major source of disability in temporal lobe
epilepsy (TLE) with unclear cellular/circuit mechanisms. Here we found that clinical TLE …

BACKGROUND Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS)
can improve seizure control for patients with drug-resistant epilepsy (DRE). Yet, one cannot …

Brain inflammation is a major factor in epilepsy, and the high mobility group box-1 (HMGB1)
protein is known to contribute significantly to the generation of seizures. Here, we …

Temporal lobe epilepsy with distributed hippocampal seizure foci is often intractable and its
secondary generalization might lead to sudden death. Early termination through spatially …

Objective Unidentified mechanisms largely restrict the viability of effective therapies in
pharmacoresistant epilepsy. Our previous study revealed that hyperactivity of the subiculum …

Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the
most common types of medically refractory epilepsy. Deep brain stimulation (DBS) shows …