PPARs as nuclear receptors for nutrient and energy metabolism

F Hong, S Pan, Y Guo, P Xu, Y Zhai - Molecules, 2019 - mdpi.com
It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …

Coordinated modulation of energy metabolism and inflammation by branched-chain amino acids and fatty acids

Z Ye, S Wang, C Zhang, Y Zhao - Frontiers in endocrinology, 2020 - frontiersin.org
As important metabolic substrates, branched-chain amino acids (BCAAs) and fatty acids
(FAs) participate in many significant physiological processes, such as mitochondrial …

BCAA metabolism and insulin sensitivity–Dysregulated by metabolic status?

NP Gannon, JK Schnuck… - Molecular nutrition & food …, 2018 - Wiley Online Library
Branched‐chain amino acids (BCAAs) appear to influence several synthetic and catabolic
cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most …

Pivotal roles of peroxisome proliferator-activated receptors (PPARs) and their signal cascade for cellular and whole-body energy homeostasis

S Lamichane, B Dahal Lamichane… - International journal of …, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor
superfamily, are important in whole-body energy metabolism. PPARs are classified into …

Roles of Peroxisome Proliferator-Activated Receptor β/δ in skeletal muscle physiology

R Manickam, W Wahli - Biochimie, 2017 - Elsevier
More than two decades of studying Peroxisome Proliferator-Activated Receptors (PPARs)
has led to an understanding of their implications in various physiological processes that are …

PGC-1α-targeted therapeutic approaches to enhance muscle recovery in aging

JJ Petrocelli, MJ Drummond - International Journal of Environmental …, 2020 - mdpi.com
Impaired muscle recovery (size and strength) following a disuse period commonly occurs in
older adults. Many of these individuals are not able to adequately exercise due to pain and …

From food to genes: transcriptional regulation of metabolism by lipids and carbohydrates

I Bravo-Ruiz, MÁ Medina, B Martínez-Poveda - Nutrients, 2021 - mdpi.com
Lipids and carbohydrates regulate gene expression by means of molecules that sense these
macronutrients and act as transcription factors. The peroxisome proliferator-activated …

Branched‐Chain Amino Acids and Mitochondrial Biogenesis: An Overview and Mechanistic Summary

JS Hinkle, CN Rivera… - Molecular Nutrition & Food …, 2022 - Wiley Online Library
Branched‐chain amino acids (BCAA) are essential in the diet and promote several vital cell
responses which may have benefits for health and athletic performance, as well as disease …

PPAR-δ and erucic acid in multiple sclerosis and Alzheimer's disease. Likely benefits in terms of immunity and metabolism

MA Altinoz, A Ozpinar - International immunopharmacology, 2019 - Elsevier
The transcription factor, PPARδ is involved in suppressing inflammation, stimulating
oligodendroglial biogenesis and myelination. Furthermore, activation of PPARδ directly …

Divergent serum metabolomic, skeletal muscle signaling, transcriptomic, and performance adaptations to fasted versus whey protein-fed sprint interval training

TP Aird, AJ Farquharson… - American Journal …, 2021 - journals.physiology.org
Sprint interval training (SIT) is a time-efficient alternative to endurance exercise, conferring
beneficial skeletal muscle metabolic adaptations. Current literature has investigated the …