Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …

The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a
fundamental functional module in the central nervous system, the NVU maintains …

Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Parkinson's disease (PD) is a common neurodegenerative disease typified by a movement
disorder consisting of bradykinesia, rest tremor, rigidity, and postural instability. Treatment …

The discovery of the central role played by the protein alpha-synuclein in Parkinson's
disease and other Lewy body brain disorders has had a great relevance in the …

The neuropathological hallmarks of Parkinson's disease (PD) are the degeneration and
death of dopamine‐producing neurons in the ventral midbrain, the widespread …

The development of new therapies to slow down or halt the progression of Parkinson's
disease is a health care priority. A key pathological feature is the presence of alpha …

Formation and aggregation of misfolded proteins in the central nervous system (CNS) is a
key hallmark of several age-related neurodegenerative diseases, including Parkinson's …

Abstract α-Synuclein is an abundant protein at the neuronal synapse that has been
implicated in Parkinson's disease for over 25 years and characterizes the hallmark …