Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing
essential roles in immune responses against microbial infections. However, over-activation …

Serine/threonine kinases (STKs) represent the majority of discovered kinases to date even
though a few Food and Drug Administration approved STKs inhibitors are reported. The third …

A lack of relevant genetic models and cell lines hampers our understanding of
hepatoblastoma pathogenesis and the development of new therapies for this neoplasm …

Liver metastasis (LM) confers poor survival and therapy resistance across cancer types, but
the mechanisms of liver-metastatic organotropism remain unknown. Here, through in vivo …

Evasion of host immunity is a hallmark of cancer; however, mechanisms linking oncogenic
mutations and immune escape are incompletely understood. Through loss-of-function …

Dysregulation of the balance between cell proliferation and cell death is a central feature of
malignances. Death-associated protein kinase 3 (DAPK3) regulates programmed cell death …

ABSTRATE N 6-methyladenosine (m6A) has been reported to be abnormally expressed in
non-small cell lung cancer (NSCLC), and plays a vital role in regulation of cell proliferation …

DAP-kinase (DAPK) is the founding member of a family of highly related, death associated
Ser/Thr kinases that belongs to the calmodulin (CaM)-regulated kinase superfamily. The …

Besides being building blocks for protein synthesis, amino acids serve a wide variety of
cellular functions, including acting as metabolic intermediates for ATP generation and for …

Abstract N 6-methyladenosine (m 6 A) has recently emerged as an important regulatory
mechanism for gene expression and aberrant m 6 A modification plays an important role in …