The rapid increase in the number of diabetic patients globally and exploration of alternate
insulin delivery methods such as inhalation or oral route that rely on higher doses, is bound …

Fundamental features of microbial cellulose utilization are examined at successively higher
levels of aggregation encompassing the structure and composition of cellulosic biomass …

Here, we describe the molecular engineering of insulin icodec to achieve a plasma half-life
of 196 h in humans, suitable for once-weekly subcutaneously administration. Insulin icodec …

Introduction Insulin icodec is a novel, long-acting insulin analog designed to cover basal
insulin requirements with once-weekly subcutaneous administration. Here we describe the …

The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …

In terms of downstream processing efficiency, secretory expression systems offer potential
advantages for the production of recombinant proteins, compared with inclusion body …

The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels
and chemicals, and it is also provides a platform for the production of many heterologous …

Bacterial inclusion bodies (IBs) are functional, non-toxic amyloids occurring in recombinant
bacteria showing analogies with secretory granules of the mammalian endocrine system …

Throughout much of the last century insulin served a central role in the advancement of
peptide chemistry, pharmacology, cell signaling and structural biology. These discoveries …

Efficient strategies for the production of recombinant proteins are gaining increasing
importance, as more applications that require high amounts of high-quality proteins reach …