The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant
neurodegenerative disorders that present principally with progressive ataxia. Within the past …

The spinocerebellar ataxias type 1 (SCA1), 2 (SCA2), 3 (SCA3), 6 (SCA6) and 7 (SCA7) are
genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs) …

Abstract Background Cerebellar Ataxias are a group of gait disorders resulting from
dysfunction of the cerebellum, commonly characterised by slowly progressing incoordination …

Background Quantitative assessment of severity of ataxia‐specific gait impairments from
wearable technology could provide sensitive performance outcome measures with high face …

Neurological disorders of gait, balance and posture are both debilitating and common.
Adequate recognition of these so-called disorders of axial mobility is important as they can …

Background We assessed the clinimetric properties of ataxia rating scales and functional
tests, and made recommendations regarding their use. Methods A systematic literature …

Neuronal atrophy in neurodegenerative diseases is commonly viewed as an early event in a
continuum that ultimately results in neuronal loss. In a mouse model of the polyglutamine …

Background The natural history of clinical symptoms in the spinocerebellar ataxias (SCA) s
has been well characterised. However there is little longitudinal data comparing cognitive …

The role of the cerebellum in cognition, both in healthy subjects and in patients with
cerebellar diseases, is debated. Neuropsychological studies in spinocerebellar ataxia type 1 …

Detecting gait phases with wearables unobtrusively and reliably in real-time is important for
clinical gait rehabilitation and early diagnosis of neurological diseases. Due to hardware …